A program for phylogenetic reconstruction using gapped data.
MAC5 is a program which implements MCMC sampling to estimate a phylogenetic tree from a DNA
multiple alignment. What differentiates MAC5 from similar programs (e.g. BAMBE, MrBayes) is
its use of five-state sequence evolution models as a means to include the gap information
when estimating an alignment. Despite vilification of these models in the literature in the
past (e.g., Durbin et al., 1998, p. 217), we have found that, in many circumstances, they are
useful for improving the precision of topology estimation.
The Mac5 distribution is available for several platforms:
- Unix: the preferred distribution due to the computational demands, Mac5 is available as a
source tarball, and so should only be used by those comfortable with compiling and installing
Unix software. This distribution includes the source, makefiles and project files for
- Macintosh: Mac5 may be compiled for Mac OS X using the above Unix tarball. Otherwise a simple
console versions (as a self-extracting archive) is available that will run on OS X and 9.
- Windows: Simple console versions (as a zipped archive) are available that will run on
Windows. This version has been only been tested lightly.
Documentation for Mac5 can be found in the distribution. Mac5 was produced with the aid of the BBSRC (Biotechnology and Biological Sciences
Research Council UK).
Note that due to life changes and the development of other software, Mac5 is no
longer being developed and is not supported.
Ultimate and final release of Mac5.
Report bugs and suggest additional features to the project manager.